Validating the association between plasma tumour necrosis factor receptor 1 levels and the presence of renal injury and functional decline in patients with Type 2 diabetes

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Title: Validating the association between plasma tumour necrosis factor receptor 1 levels and the presence of renal injury and functional decline in patients with Type 2 diabetes
Authors: Doody, Alison
Jackson, Sabrina
Elliott, Jessie
Godson, Catherine
le Roux, Carel W.
Docherty, Neil G.
et al.
Permanent link: http://hdl.handle.net/10197/9836
Date: 18-Sep-2017
Online since: 2019-04-08T10:17:02Z
Abstract: AIMS: Elevated plasma soluble tumour necrosis factor receptor 1 (TNFR1) predicts long-term progression of chronic kidney disease. We investigated the association between elevated TNFR1 and the presence of renal disease in patients with Type 2 diabetes mellitus registering a haemoglobin A1c (HbA1c) >48mmol/mol despite medical therapy. METHODS: Using sensitivity, specificity and regression analyses we interrogated the association between plasma TNFR1 and presence of chronic kidney disease as assessed by the presence of microalbuminuria and/or an estimated glomerular filtration rate of less than 60ml/min/1.73m2 (stages 3-5 chronic kidney disease). The association of TNFR1 with C-reactive protein and leptin-adiponectin ratio as plasma markers of systemic inflammation and adipose stress respectively was also investigated. RESULTS: Upper quartile TNFR1 is independently associated with elevated urinary albumin-creatinine ratios, reductions in eGFR and strongly predicts the presence of stages 3-5 chronic kidney disease in regression modelling. Elevated TNFR1 levels are associated with increased plasma C-reactive protein and augmented leptin-adiponectin ratio. CONCLUSIONS: Our study confirms plasma TNFR1 as a surrogate of renal structural and functional impairment in patients with type 2 diabetes mellitus. Association of TNFR1 with markers of systemic inflammation and adipose stress indicates that TNFR1 may be a biomarker of these processes as components of the pathogenesis of diabetic kidney disease.
Funding Details: Science Foundation Ireland
University College Dublin Foundation
Type of material: Journal Article
Publisher: Elsevier
Journal: Journal of Diabetes and its Complications
Volume: 32
Issue: 1
Start page: 95
End page: 99
Copyright (published version): 2017 Elsevier
Keywords: Diabetic kidney diseaseBiomarkersProgressionTNFR1Leptin-adiponectin ratioC-reactive protein
DOI: 10.1016/j.jdiacomp.2017.09.007
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection

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