Validating the association between plasma tumour necrosis factor receptor 1 levels and the presence of renal injury and functional decline in patients with Type 2 diabetes
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|Title:||Validating the association between plasma tumour necrosis factor receptor 1 levels and the presence of renal injury and functional decline in patients with Type 2 diabetes||Authors:||Doody, Alison
le Roux, Carel W.
Docherty, Neil G.
|Permanent link:||http://hdl.handle.net/10197/9836||Date:||18-Sep-2017||Online since:||2019-04-08T10:17:02Z||Abstract:||AIMS: Elevated plasma soluble tumour necrosis factor receptor 1 (TNFR1) predicts long-term progression of chronic kidney disease. We investigated the association between elevated TNFR1 and the presence of renal disease in patients with Type 2 diabetes mellitus registering a haemoglobin A1c (HbA1c) >48mmol/mol despite medical therapy. METHODS: Using sensitivity, specificity and regression analyses we interrogated the association between plasma TNFR1 and presence of chronic kidney disease as assessed by the presence of microalbuminuria and/or an estimated glomerular filtration rate of less than 60ml/min/1.73m2 (stages 3-5 chronic kidney disease). The association of TNFR1 with C-reactive protein and leptin-adiponectin ratio as plasma markers of systemic inflammation and adipose stress respectively was also investigated. RESULTS: Upper quartile TNFR1 is independently associated with elevated urinary albumin-creatinine ratios, reductions in eGFR and strongly predicts the presence of stages 3-5 chronic kidney disease in regression modelling. Elevated TNFR1 levels are associated with increased plasma C-reactive protein and augmented leptin-adiponectin ratio. CONCLUSIONS: Our study confirms plasma TNFR1 as a surrogate of renal structural and functional impairment in patients with type 2 diabetes mellitus. Association of TNFR1 with markers of systemic inflammation and adipose stress indicates that TNFR1 may be a biomarker of these processes as components of the pathogenesis of diabetic kidney disease.||Funding Details:||Science Foundation Ireland
University College Dublin Foundation
|Type of material:||Journal Article||Publisher:||Elsevier||Journal:||Journal of Diabetes and its Complications||Volume:||32||Issue:||1||Start page:||95||End page:||99||Copyright (published version):||2017 Elsevier||Keywords:||Diabetic kidney disease; Biomarkers; Progression; TNFR1; Leptin-adiponectin ratio; C-reactive protein||DOI:||10.1016/j.jdiacomp.2017.09.007||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Conway Institute Research Collection|
Medicine Research Collection
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