Effects of a casein hydrolysate versus intact casein on gastric emptying and amino acid responses
Files in This Item:
File | Size | Format | |
---|---|---|---|
Download | Horner_et_al_2018.docx | 448.7 kB | Microsoft Word |
Title: | Effects of a casein hydrolysate versus intact casein on gastric emptying and amino acid responses | Authors: | Horner, Katy M.; Drummond, Elaine; O'Sullivan, Victoria; Pedapati, S.C. Sri Harsha; Brennan, Lorraine | Permanent link: | http://hdl.handle.net/10197/9875 | Date: | 10-Jan-2018 | Online since: | 2019-04-10T07:42:11Z | Abstract: | Purpose Milk proteins and/or their hydrolysates have been reported to have beneficial effects for improving postprandial glycaemia. Gastric emptying is a major determinant of postprandial glycaemia, yet limited studies have examined the effects of intact milk proteins compared to hydrolysates on gastric emptying. We investigated gastric emptying of a casein hydrolysate compared to intact casein. Methods Nine overweight and obese adults (mean ± SD age: 59.5 ± 6.5 years and BMI 28.4 ± 2.6 kg/m2) were studied in a randomised crossover design. Gastric emptying was assessed by paracetamol absorption test, with HPLC-MS being used for determining paracetamol and its primary metabolites in plasma. Glucose, insulin and amino acid responses were also assessed. Results Linear mixed model analysis showed no effect of treatment [F(1, 55) = 2.1, P = 0.16] or treatment × time interactions [F(6, 54) = 1.5, P = 0.21] for paracetamol concentrations. In addition, there were no significant differences between the intact casein and hydrolysate for any of the gastric emptying outcome measures (Cmax, AUC0–30min, AUC0–60min; AUC0–240min). However, insulin was increased in the early postprandial period (iAUC0–15min, iAUC0–30min; P < 0.05) and there was a treatment effect for glucose [F(1, 53) = 5.3, P = 0.03] following the casein hydrolysate compared to intact casein. No significant differences in amino acids were found between the two conditions. Conclusions Gastric emptying of a casein hydrolysate compared to intact casein does not differ. Mechanisms other than gastric emptying, for example the presence of a bioactive peptide sequence, may contribute to the glycaemic management effects of certain milk protein hydrolysates and warrant further investigation. | Funding Details: | Enterprise Ireland | Type of material: | Journal Article | Publisher: | Springer | Journal: | European Journal of Nutrition | Start page: | 1 | End page: | 10 | Copyright (published version): | 2018 Springer | Keywords: | Casein; Gastric emptying; Hydrolysate; Postprandial glycaemia | DOI: | 10.1007/s00394-018-1610-8 | Language: | en | Status of Item: | Peer reviewed | ISSN: | 1436-6207 | This item is made available under a Creative Commons License: | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ |
Appears in Collections: | Institute of Food and Health Research Collection Public Health, Physiotherapy and Sports Science Research Collection Agriculture and Food Science Research Collection |
Show full item record
SCOPUSTM
Citations
50
3
Last Week
0
0
Last month
0
0
checked on Sep 12, 2020
Page view(s)
786
Last Week
2
2
Last month
19
19
checked on May 19, 2022
Download(s) 50
278
checked on May 19, 2022
Google ScholarTM
Check
Altmetric
If you are a publisher or author and have copyright concerns for any item, please email research.repository@ucd.ie and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.