Effects of a casein hydrolysate versus intact casein on gastric emptying and amino acid responses
|Title:||Effects of a casein hydrolysate versus intact casein on gastric emptying and amino acid responses||Authors:||Horner, Katy M.; Drummond, Elaine; O'Sullivan, Victoria; Pedapati, S.C. Sri Harsha; Brennan, Lorraine||Permanent link:||http://hdl.handle.net/10197/9875||Date:||10-Jan-2018||Online since:||2019-04-10T07:42:11Z||Abstract:||Purpose Milk proteins and/or their hydrolysates have been reported to have beneficial effects for improving postprandial glycaemia. Gastric emptying is a major determinant of postprandial glycaemia, yet limited studies have examined the effects of intact milk proteins compared to hydrolysates on gastric emptying. We investigated gastric emptying of a casein hydrolysate compared to intact casein. Methods Nine overweight and obese adults (mean ± SD age: 59.5 ± 6.5 years and BMI 28.4 ± 2.6 kg/m2) were studied in a randomised crossover design. Gastric emptying was assessed by paracetamol absorption test, with HPLC-MS being used for determining paracetamol and its primary metabolites in plasma. Glucose, insulin and amino acid responses were also assessed. Results Linear mixed model analysis showed no effect of treatment [F(1, 55) = 2.1, P = 0.16] or treatment × time interactions [F(6, 54) = 1.5, P = 0.21] for paracetamol concentrations. In addition, there were no significant differences between the intact casein and hydrolysate for any of the gastric emptying outcome measures (Cmax, AUC0–30min, AUC0–60min; AUC0–240min). However, insulin was increased in the early postprandial period (iAUC0–15min, iAUC0–30min; P < 0.05) and there was a treatment effect for glucose [F(1, 53) = 5.3, P = 0.03] following the casein hydrolysate compared to intact casein. No significant differences in amino acids were found between the two conditions. Conclusions Gastric emptying of a casein hydrolysate compared to intact casein does not differ. Mechanisms other than gastric emptying, for example the presence of a bioactive peptide sequence, may contribute to the glycaemic management effects of certain milk protein hydrolysates and warrant further investigation.||Funding Details:||Enterprise Ireland||Type of material:||Journal Article||Publisher:||Springer||Journal:||European Journal of Nutrition||Start page:||1||End page:||10||Copyright (published version):||2018 Springer||Keywords:||Casein; Gastric emptying; Hydrolysate; Postprandial glycaemia||DOI:||10.1007/s00394-018-1610-8||Language:||en||Status of Item:||Peer reviewed||ISSN:||1436-6207||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by-nc-nd/3.0/ie/|
|Appears in Collections:||Institute of Food and Health Research Collection|
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