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Sridhar, Karthik
Preferred name
Sridhar, Karthik
Official Name
Sridhar, Karthik
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Now showing 1 - 2 of 2
- PublicationEstimation of dispersive properties of encapsulation tissue surrounding deep brain stimulation electrodes in the ratThe aim of this study was to estimate the electrical properties of the encapsulation tissue surrounding chronically implanted electrodes for deep brain stimulation in the rat. The impedance spectrum of a concentric bipolar microelectrode implanted in the rat brain was measured immediately following surgery and after 8 weeks of implantation. The experimental impedance data were used in combination with a finite element model of the rat brain using a parametric sweep method to estimate the electrical properties of the tissue surrounding the electrode in acute and chronic conditions. In the acute case, the conductivity and relative permittivity of the peri-electrode space were frequency independent with an estimated conductivity of 0.38 S/m and relative permittivity of 123. The electrical properties of the encapsulation tissue in the chronic condition were fitted to a dispersive Cole-Cole model. The estimated conductivity and relative permittivity in the chronic condition at 1 kHz were 0.028 S/m and 2×10 5 , respectively. The estimated tissue properties can be used in combination with computational modeling as a basis for optimization of chronically implanted electrodes to increase the efficacy of long-term neural recording and stimulation.
358Scopus© Citations 1 - PublicationFeasibility of pair-housing of rats after cranial implant surgeryRat models employing cranial implants are increasingly employed to facilitate neural stimulation and recording in freely moving animals. Due to possible damage to wound, implant or attached devices, rats with cranial implants are traditionally housed singly, and little information is available on group- or pair-housing. Here we describe a protocol for pair-housing rats following cranial implant surgery and describe our experience with pair-housing during post-surgical recovery and up to 16 weeks following surgery.Thirty-six adult Wistar rats of both sexes were implanted with deep brain stimulation electrodes. Ten rats were equipped with an additional wireless headstage. Rats were housed in stable pairs before surgery and re-introduced 0-18 h post-surgery. Rat grimace scores did not indicate pain after conclusion of the analgesia protocol, physiological parameters were in the normal range three days post-surgery and weight loss did not exceed 10%. Rats with a cement cap only were pair-housed continuously without damage to the headcap. Rats carrying an additional fragile headstage had to be separated during lights-off periods to prevent headstage damage but could be pair-housed during lights-on periods. Pair-housing is a feasible and effective method to facilitate the rats' need for social companionship following cranial implant surgery.
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