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Quinn, Susan J.
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Quinn, Susan J.
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Quinn, Susan J.
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Now showing 1 - 10 of 26
- PublicationUltra Laser Facility Applications for Chemistry, Life Sciences and Catalysis(2016-09-30)
; ; ; ; We describe ULTRA laser facility applications for chemistry, life sciences and catalysis, illustrated by vibrational control of electron transfer; photoinduced electron transfer in DNA crystals; and operando Kerr-gated Raman insight into catalytic hydrocarbon conversion with zeolites50 - PublicationSpectro-electrochemical Studies on [Ru(TAP)2 (dppz)]2+ - Insights into the Mechanism of its Photosensitized Oxidation of Oligonucleotides(American Chemical Society, 2019-01-07)
; ; ; [Ru(TAP) 2 (dppz)] 2+ (TAP = 1,4,5,8-tetraazaphenanthrene; dppz = dipyrido[3,2-a:2′,3′-c]phenazine) is known to photo-oxidize guanine in DNA. Whether this oxidation proceeds by direct photoelectron transfer or by proton-coupled electron transfer is still unknown. To help distinguish between these mechanisms, spectro-electrochemical experiments have been carried out with [Ru(TAP) 2 (dppz)] 2+ in acetonitrile. The UV-vis and mid-IR spectra obtained for the one-electron reduced product were compared to those obtained by picosecond transient absorption and time-resolved infrared experiments of [Ru(TAP) 2 (dppz)] 2+ bound to guanine-containing DNA. An interesting feature of the singly reduced species is an electronic transition in the near-IR region (with λ max at 1970 and 2820 nm). Density functional and time-dependent density functional theory simulations of the vibrational and electronic spectra of [Ru(TAP) 2 (dppz)] 2+ , the reduced complex [Ru(TAP) 2 (dppz)] + , and four isomers of [Ru(TAP)(TAPH)(dppz)] 2+ (a possible product of proton-coupled electron transfer) were performed. Significantly, these predict absorption bands at λ > 1900 nm (attributed to a ligand-to-metal charge-transfer transition) for [Ru(TAP) 2 (dppz)] + but not for [Ru(TAP)(TAPH)(dppz)] 2+ . Both the UV-vis and mid-IR difference absorption spectra of the electrochemically generated singly reduced species [Ru(TAP) 2 (dppz)] + agree well with the transient absorption and time-resolved infrared spectra previously determined for the transient species formed by photoexcitation of [Ru(TAP) 2 (dppz)] 2+ intercalated in guanine-containing DNA. This suggests that the photochemical process in DNA proceeds by photoelectron transfer and not by a proton-coupled electron transfer process involving formation of [Ru(TAP)(TAPH)(dppz)] 2+ , as is proposed for the reaction with 5′-guanosine monophosphate. Additional infrared spectro-electrochemical measurements and density functional calculations have also been carried out on the free TAP ligand. These show that the TAP radical anion in acetonitrile also exhibits strong broad near-IR electronic absorption (λ max at 1750 and 2360 nm).126Scopus© Citations 9 - PublicationPhotophysical studies of CdTe quantum dots in the presence of a zinc cationic porphyrin(RSC Publishing, 2012-09-24)
; ; ; ; ; ; ; ; ; The photophysical properties of 2.3 nm thioglycolic acid (TGA) coated CdTe quantum dots (QDs) prepared by a reflux method have been studied in the presence of cationic meso-tetrakis(4-N-methylpyridyl) zinc porphyrin (ZnTMPyP4). Addition of the CdTe QDs to the porphyrin in H2O results in a marked red-shift and hypochromism in the porphyrin absorption spectrum, indicative of a non-covalent binding interaction with the QD surface. Only low equivalents of the quantum dot were required for complete quenching of the porphyrin fluorescence revealing that one quantum dot may quench more than one porphyrin. Similarly addition of porphyrin to the quantum dot provided evidence for very efficient quenching of the CdTe photoluminescence, suggesting the formation of CdTe'porphyrin aggregates. Definitive evidence for such aggregates was gathered using small angle X-ray spectroscopy (SAXS). Ultrafast transient absorption data are consistent with very rapid photoinduced electron transfer (1.3 ps) and the resultant formation of a long-lived porphyrin species.450Scopus© Citations 25 - PublicationUltrafast IR spectroscopy of polymeric cytosine nucleic acids reveal the long-lived species is due to a localised state(RSC Publishing, 2012-02-22)
; ; ; ; ; ; ; ; ; The decay pathways of UV-excited cytosine polymers are investigated using picosecond time-resolved infrared spectroscopy. Similar yields of a non-emissive (1)nÏ * state are found in the single-stranded dC(30) polymer as in the dCMP monomer, but with a longer lifetime in the polymer (80 ps vs. 39 ps). A longer lifetime is also found in the d(CpC) dinucleotide. No evidence of excimer states is observed, suggesting that localised (1)nÏ * excited states are the most significant intermediates present on the picosecond timescale.334Scopus© Citations 11 - PublicationQuaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation.(RSC Publishing, 2011)
; ; ; ; ; The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.341Scopus© Citations 36 - PublicationSynthesis and photophysical evaluations of fluorescent quaternary bipyridyl-1,8-naphthalimide conjugates as nucleic acid targeting agents(Taylor & Francis, 2012-01-16)
; ; ; A family of organic molecules containing the DNA intercalating chromophores, 4-nitro- and 4-amino 1,8-naphthalimide, conjugated to a diquat derivative by an ‘orthogonal’ phenyl spacer have been prepared and characterised. Their binding interactions with double-stranded DNA were studied by a variety of spectroscopic techniques. These charged organic compounds are found to exhibit excellent binding affinities to DNA with binding constants comparable to those exhibited by metal complexes.514Scopus© Citations 19 - PublicationRecent developments in carbon nanomaterial sensors(Royal Society of Chemistry, 2015-05-18)
; ; ; Carbon nanomaterials are among the most broadly discussed, researched and applied of synthetic nanomaterials. The structural diversity of these materials provides an array of unique electronic, magnetic and optical properties, which when combined with their robust chemistry and ease of manipulation, makes them attractive candidates for sensor applications. Furthermore, the biocompatibility exhibited by many carbon nanomaterials has seen them used as in vivo biosensors. Carbon nanotubes, graphene and carbon dots have come under intense scrutiny, as either discrete molecular-like sensors, or as components which can be integrated into devices. In this review we consider recent developments in the use of carbon nanoparticles and nanostructures as sensors and consider how they can be used to detect a diverse range of analytes.695Scopus© Citations 372 - PublicationGreen Synthesis of Metal Nanoparticles via Natural Extracts: The Biogenic Nanoparticle Corona and Its Effects on Reactivity(American Chemical Society, 2015-05-25)
; ; ; ; ; The optical and catalytic properties of metal nanoparticles have attracted significant attention for applications in a wide variety of fields, thus prompting interest in developing sustainable synthetic strategies that leverage the redox properties of natural compounds or extracts. Here, we investigate the surface chemistry of nanoparticles synthesized using coffee as a biogenic reductant. Building on our previously developed synthetic protocols for the preparation of silver and palladium nanoparticle/carbon composite microspheres, a combination of thermogravimetric and spectroscopic methods was used to characterize the carbon microsphere and nanoparticle surfaces. Infrared reflectance spectroscopy and single particle surface enhanced Raman spectroscopy were used to characterize Pd and Ag metal surfaces, respectively, following synthesis. Strongly adsorbed organic layers were found to be present at metal nanoparticle surfaces after synthesis. The catalytic activity of Pd nanoparticles in hydrogenation reactions was leveraged to study the availability of surface sites, and coffee-synthesized nanomaterials were compared to commercial Pd-based hydrogenation catalysts. Our results demonstrate that biogenic adsorbates block catalytic surface sites and affect nanoparticle functionality. These findings highlight the need for careful analysis of surface chemistry as it relates to the specific applications of nanomaterials produced using greener or more sustainable methods. (Figure Presented).325Scopus© Citations 68 - PublicationTracking DNA excited states by picosecond-time-resolved infrared spectroscopy: Signature band for a charge-transfer excited state in stacked adenine-thymine systems(American Chemical Society, 2013-07-29)
; ; ; ; UV photoexcitation of an adenine-thymine heterodimer (ApT) in D 2O yields a complex transient infrared signature in the 1500-1600 cm-1 spectral region. The spectral dynamics fit well to a biexponential decay assignable to two transient species. The first, a short-lived species with a lifetime of ca. 5 ps, originates from the vibrationally hot electronic ground state of the unstacked form of the dinucleotide. The second species is longer-lived (ca. 75 ps), and its yield correlates to the amount of stacked dinucleotide present in solution. We assign the longer-lived component to a charge-transfer (A•+pT •-) state by comparison with calculated spectra for the adenine radical cation and thymine radical anion. Significantly, the CT feature is also identified in UV-excited [poly(dA-dT)]2. This experimental observation gives a powerful insight into how base-base interactions lead to extended-lifetime electronic excited states of the nucleic acid bases and how a dimeric structure controls the relaxation pathway. © 2013 American Chemical Society.164Scopus© Citations 69 - PublicationMonitoring guanine photo-oxidation by enantiomerically resolved Ru(II) dipyridophenazine complexes using inosine-substituted oligonucleotides(Royal Society of Chemistry, 2015-10-01)
; ; ; ; The intercalating [Ru(TAP)2(dppz)]2+ complex can photo-oxidise guanine in DNA, although in mixed-sequence DNA it can be difficult to understand the precise mechanism due to uncertainties in where and how the complex is bound. Replacement of guanine with the less oxidisable inosine (I) base can be used to understand the mechanism of electron transfer (ET). Here the ET has been compared for both Λ- and Δ-enantiomers of [Ru(TAP)2(dppz)]2+ in a set of sequences where guanines in the readily oxidisable GG step in {TCGGCGCCGA}2 have been replaced with I. The ET has been monitored using picosecond and nanosecond transient absorption and picosecond time-resolved IR spectroscopy. In both cases inosine replacement leads to a diminished yield, but the trends are strikingly different for Λ- and Δ-complexes.89Scopus© Citations 13
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