Brayden, David JamesDavid JamesBraydenBaird, Alan W.Alan W.Baird2019-08-142019-08-142019, Mass2019-04-25New England Journal of Medicine0028-4793http://hdl.handle.net/10197/10986Oral ingestion remains the preferred method of drug administration. Its disadvantages with regard to biologic agents reflect the fact that systemic bioavailability is influenced by the chemical properties of the drug and by the gastrointestinal physiological and pathologic features of the patient. Unfortunately, many candidate biologic agents are labile or cannot readily cross the gastrointestinal epithelium.PrintenStomachDrug Delivery SystemsFood MicrobiologyJournal Article380171671167310.1056/NEJMcibr19017662019-08-09https://creativecommons.org/licenses/by-nc-nd/3.0/ie/