Fulaz, StephanieStephanieFulazVitale, StefaniaStefaniaVitaleQuinn, LauraLauraQuinnCasey, EoinEoinCasey2023-02-082023-02-082019 Elsev2019-11Trends in Microbiology0966-842Xhttp://hdl.handle.net/10197/24175The negative consequences of biofilms are widely reported. A defining feature of biofilms is the extracellular matrix, a complex mixture of biomacromolecules, termed EPS, which contributes to reduced antimicrobial susceptibility. EPS targeting is a promising, but underexploited, approach to biofilm control allowing disruption of the matrix and thereby increasing the susceptibility to antimicrobials. Nanoparticles (NPs) can play a very important role as ’carriers’ of EPS matrix disruptors, and several approaches have recently been proposed. In this review, we discuss the application of nanoparticles as antibiofilm technologies with a special emphasis on the role of the EPS matrix in the physicochemical regulation of the nanoparticle–biofilm interaction. We highlight the use of nanoparticles as a platform for a new generation of antibiofilm approaches.Print-ElectronicenThis is the author’s version of a work that was accepted for publication in Trends in Microbiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Microbiology (VOL 27, ISSUE 11, (2019)) DOI: https://doi.org/10.1016/j.tim.2019.07.004BiofilmNanoparticleBiofilm–nanoparticle interactionExtracellular polymeric substanceBiofilm matrixReview271191592610.1016/j.tim.2019.07.0042022-12-1415/IA/3008https://creativecommons.org/licenses/by/3.0/ie/