Keane, Páraic M.Páraic M.KeanePoynton, Fergus E.Fergus E.PoyntonHall, James P.James P.HallQuinn, Susan J.Susan J.Quinn2020-09-292020-09-292015 the A2015-07-13Angewandte Chemie - International Edition1433-7851http://hdl.handle.net/10197/11605Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ-[Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ versus 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.Print-ElectronicenRutheniumGuaninePhenazinesDNAIntercalating agentsCrystallography, X-rayBase sequenceBase pairingOxidation-reductionLightModels, molecularCoordination complexesJournal Article54298364836810.1002/anie.2015026082020-09-21https://creativecommons.org/licenses/by-nc-nd/3.0/ie/