Almohammed, SawsanSawsanAlmohammedFularz, AgataAgataFularzZhang, FengyuanFengyuanZhangAlvarez-Ruiz, DianaDianaAlvarez-RuizRodriguez, Brian J.Brian J.RodriguezRice, James H.James H.Riceet al.2021-03-022021-03-022020 Ameri2020-10-15ACS Applied Materials & Interfaces1944-8244http://hdl.handle.net/10197/11995Piezoelectric quasi-1D peptide nanotubes and plasmonic metal nanoparticles are combined to create a flexible and self-energized surface-enhanced Raman spectroscopy (SERS) substrate that strengthens SERS signal intensities by over an order of magnitude compared to an unflexed substrate. The platform is used to sense bovine serum albumin, lysozyme, glucose, and adenine. Finite-element electromagnetic modeling indicates that the signal enhancement results from piezoelectric-induced charge, which is mechanically activated via substrate bending. The results presented here open the possibility of using peptide nanotubes on conformal substrates for in situ SERS detection.Print-ElectronicenThis document is the Accepted Manuscript version of a Published Work that appeared in final form inACS Applied Materials & Interfaces, copyright © 2020 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.0c15498DiphenylalanineNanostructuresPeptidePiezoelectricSelf-energizedSurface-enhanced Raman spectroscopyJournal Article1243488744888110.1021/acsami.0c154982020-11-0707/IN.1/B93112/IP/155614/US/I3113IR1016118/TIDA/613912/IP/155617/CDA/463771356712/RC/227812/RC/2278 P2https://creativecommons.org/licenses/by-nc-nd/3.0/ie/