Taday, FreyaFreyaTadayCairns, RyanRyanCairnsO'Connell, AdamAdamO'ConnellO'Reilly, ElaineElaineO'Reilly2023-01-202023-01-202022 Royal2022-02-07Chemical Communications1359-7345http://hdl.handle.net/10197/24142There is continued interest in developing cascade processes for the synthesis of key chiral building blocks and bioactive natural products (or analogues). Here, we report a hybrid bio-organocatalytic cascade for the synthesis of a small panel of 2-substituted piperidines, relying on a transaminase to generate a key reactive intermediate for the complexity building Mannich reaction.ElectronicenPiperidinesCascade processesChemical synthesisJournal Article58111697170010.1039/d1cc03865f2023-01-2019/FFP/6469https://creativecommons.org/licenses/by-nc-nd/3.0/ie/