Amadio, JessicaJessicaAmadioGordon, KatherineKatherineGordonMurphy, Cormac D.Cormac D.Murphy2012-09-042012-09-042010 Ameri2010-09Applied and Environmental Microbiologyhttp://hdl.handle.net/10197/3780The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4’-hydroxyflurbiprofen was isolated by preparative HPLC. C. elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments.enFluorineAnti-inflammatory agentsBiotransformation (Metabolism)MucoralesJournal Article76186299630310.1128/AEM.01027-10https://creativecommons.org/licenses/by-nc-sa/1.0/