Almohammed, SawsanSawsanAlmohammedAlruwaili, MahaMahaAlruwailiReynaud, Emmanuel G.Emmanuel G.ReynaudRedmond, GarethGarethRedmondRice, James H.James H.RiceRodriguez, Brian J.Brian J.Rodriguez2019-08-122019-08-122019 Ameri2019-07-26ACS Applied Nano Materials2574-0970http://hdl.handle.net/10197/10962Precise control over the arrangement of plasmonic nanomaterials is critical for label-free single-molecule surface-enhanced Raman spectroscopy (SERS)-based sensing applications. SERS templates should provide high sensitivity and reproducibility and be cost-effective and easy to prepare. Additive manufacturing by extrusion-based three-dimensional (3D) printing is an emerging technique for the spatial arrangement of nanomaterials and is a method that may satisfy these SERS template requirements. In this work, we use 3D printing to produce sensitive and reproducible SERS templates using a fluorenylmethyloxycarbonyl diphenylalanine (Fmoc-FF) hydrogel loaded with silver or gold nanoparticles. The Fmoc-FF template allows the detection of low Raman cross-section molecules such as adenine at concentrations as low as 100 pM.enThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © 2019 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/10.1021/acsanm.9b009403D bioprintingAdditive manufacturingPeptidesFmocDiphenylalanineRamanSERSSERRSJournal Article25029503410.1021/acsanm.9b009402019-08-08IR10161IR1013364417516/IA/458413/TIDA/B270112/IP/1556https://creativecommons.org/licenses/by-nc-nd/3.0/ie/