Di Filippo, MaraMaraDi FilippoBaumann, MarcusMarcusBaumann2021-11-092021-11-092020 Wiley2020-10-22European Journal of Organic Chemistry1434-193Xhttp://hdl.handle.net/10197/12603A continuous photochemical process is presented that renders a series of quinoline products via an alkene isomerization and cyclocondensation cascade. It is demonstrated that a high-power LED lamp generates the desired targets with higher productivity and efficiency than a medium-pressure Hg-lamp. The scope of this tandem process is established and allows for the generation of various substituted quinolines in high yields and with throughputs of greater than one gram per hour. Finally, this effective flow process is coupled with a telescoped hydrogenation reaction to render a series of tetrahydroquinolines including the antimalarial natural product galipinine.enThis is the peer reviewed version of the following article: Di Filippo, M. and Baumann, M. (2020), Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization‐Cyclization Process. Eur. J. Org. Chem., 2020: 6199-6211., which has been published in final form at https://doi.org/10.1002/ejoc.202000957. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.QuinolineTetrahydroquinolineFlow chemistryPhotochemistryGalipinine alkaloidBiologically active quinolineAlkaloidsHydrogenationDrugsMetalEsterJournal Article396199621110.1002/ejoc.2020009572020-09-2112/RC/2275_P2https://creativecommons.org/licenses/by-nc-nd/3.0/ie/