A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

Donnelly, KianKianDonnellyBaumann, MarcusMarcusBaumann2023-05-092023-05-092021-03-21Chemical Communications1359-7345http://hdl.handle.net/10197/24398A continuous flow process to generate [1.1.1]propellane on demand is presented rendering solutions of [1.1.1]propellane that can directly be derivatised into various bicyclo[1.1.1]pentane (BCP) species. This was realised in throughputs up to 8.5 mmol h-1providing an attractive and straightforward access to gram quantities of selected BCP building blocks. Lastly, a continuous photochemical transformation of [1.1.1]propellane into valuable BCPs bearing mixed ester/acyl chloride moieties was developed.PrintenContinuous flow chemistry[1.1.1]propellaneContinuous photochemical transformationA continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivativesJournal Article57232871287410.1039/d0cc08124h2021-08-2918/RI/570212/RC2275_P2https://creativecommons.org/licenses/by-nc-nd/3.0/ie/