Stephens, NiamhNiamhStephensRawlings, BernardBernardRawlingsCaffrey, PatrickPatrickCaffrey2017-01-202017-01-202013-05-22Bioscience Biotechnology and Biochemistryhttp://hdl.handle.net/10197/8288Actinoplanes caeruleus produces 67-121C, a heptaene macrolide modified with a D-mannosyl-D-mycosaminyl disaccharide. Draft genome sequencing revealed genes encoding mycosaminyltransferase, mycosamine synthase, a cytochrome P450 that modifies the macrolactone core, and the extending mannosyltransferase. Only the mycosamine synthase and P450 were active in the biosynthesis of amphotericins in Streptomyces nodosus, the amphotericin producer.enThis is an electronic version of an article published in Bioscience Biotechnology and Biochemistry 77(4): 880-883 (2013). Bioscience Biotechnology and Biochemistry is available online at: www.tandfonline.com/doi/abs/10.1271/bbb.120961.Polyene macrolide biosynthesisExtending glycosyltransferaseVersatility of enzymes catalyzing late steps in polyene 67-121C biosynthesisEnzymes Catalyzing Late Steps in 67-121C BiosynthesisJournal Article77488088310.1271/bbb.1209612017-01-04https://creativecommons.org/licenses/by-nc-nd/3.0/ie/