Balducci, DanieleDanieleBalducciConway, Philip A.Philip A.ConwaySapuppo, GiuliaGiuliaSapuppoMüller-Bunz, HelgeHelgeMüller-BunzParadisi, FrancescaFrancescaParadisi2012-08-242012-08-242012 Elsev2012-09Tetrahedronhttp://hdl.handle.net/10197/3764A new practical and efficient synthesis of alpha-keto acids was accomplished starting from the synthon 1,4-diacetylpiperazine-2,5-dione. The synthesis encompasses both aromatic and aliphatic substrates proving to be versatile and innovative with excellent carbon economy and recycling of the glycine by-product.enThis is the author’s version of a work that was accepted for publication in Tetrahedron. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron (VOL 68, ISSUE 36, (2012)) DOI:10.1016/j.tet.2012.06.078 Elsevier Ltd. Elsevier B.V. Elsevier Inc.Alpha-keto acidsAliphaticAromaticAldol reactionKetonic acids--SynthesisAliphatic compounds--SynthesisAromatic compounds--SynthesisJournal Article68367374737910.1016/j.tet.2012.06.078https://creativecommons.org/licenses/by-nc-sa/1.0/