Amadio, JessicaJessicaAmadioMurphy, Cormac D.Cormac D.Murphy2012-09-042012-09-042009 Sprin2010Applied Microbiology and Biotechnologyhttp://hdl.handle.net/10197/3782The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants with a variety of analytical techniques. 4-Fluorobiphenyl was principally transformed to 4-fluoro-4′-hydroxybiphenyl, but other mono- and dihydroxylated compounds were detected in organic extracts by gas chromatography–mass spectrometry. Additionally, fluorinated water-soluble products were detected by 19F NMR and were identified as sulphate and β-glucuronide conjugates. Other fluorobiphenyls (2-fluoro-, 4,4′-difluoro- and 2,3,4,5,6-pentafluoro-biphenyl) were catabolised by C. elegans, yielding mono- and dihydroxylated products, but phase II metabolites were detected from 4,4′-difluorobiphenyl only.enThe final publication is available at www.springerlink.comFluorineBiphenylMetabolismF-19 NMRFluorineBiphenyl compoundsBiotransformation (Metabolism)MucoralesJournal Article86134535110.1007/s00253-009-2346-4https://creativecommons.org/licenses/by-nc-sa/1.0/