Baumann, MarcusMarcusBaumannBaxendale, Ian R.Ian R.BaxendaleDeplante, FabienFabienDeplante2021-11-092021-11-092017 the A2017-11-29Beilstein Journal of Organic Chemistry1860-5397http://hdl.handle.net/10197/12602An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams.Electronic-eCollectionenThis is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)Flow chemistryHeterocycleHydrogenationIndoleMultistepSiubstituted indolesHydrogenationOptimizationDerivativesJournal Article132549256010.3762/bjoc.13.2512020-09-23https://creativecommons.org/licenses/by/3.0/ie/