Brayden, David JamesDavid JamesBrayden2021-03-082021-03-082020-05-11Nature Biomedical Engineering2157-846Xhttp://hdl.handle.net/10197/12014The delivery of therapeutic peptides via the oral route remains a great challenge for the pharmaceutical industry. Oral delivery is the most convenient administration route, as it leads to higher patient compliance than for sub-cutaneous and intra-muscular injections and, for some chronic diseases, to earlier adoption of treatment.enThis is a post-peer-review, pre-copyedit version of an article published in Nature Biomedical Engineering. The final authenticated version is available online at: https://doi.org/10.1038/s41551-020-0559-0Drug deliveryDrug developmentGastrointestinal systemMolecular medicineJournal Article448748810.1038/s41551-020-0559-02020-05-22https://creativecommons.org/licenses/by-nc-nd/3.0/ie/