O'Reilly, ElaineElaineO'ReillyPes, LaraLaraPesParadisi, FrancescaFrancescaParadisi2012-06-132012-06-132010 Elsev2010-03-31Tetrahedron Lettershttp://hdl.handle.net/10197/3639An efficient one-pot synthesis is described for the preparation of 1,4-disubstituted piperazine-2,5-diones starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting chloroacetamide is cyclised in situ by employing the phase-transfer (PT) catalyst, benzyltriethylammonium chloride (TEBA). The products are isolated in excellent yields of up to 90%.98304 bytesapplication/mswordenThis is the author’s version of a work that was accepted for publication in Tetrahedron Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron Letters (2010) DOI: 10.1016/j.tetlet.2010.01.075DiketopiperazineOne-pot synthesisPhase-transfer catalystBenzyltriethylammonium chlorideOrganic cyclic compounds--SynthesisPhase-transfer catalystsChloridesJournal Article51131696169710.1016/j.tetlet.2010.01.075https://creativecommons.org/licenses/by-nc-sa/1.0/