O'Reilly, ElaineElaineO'ReillyLestini, ElenaElenaLestiniBalducci, DanieleDanieleBalducciParadisi, FrancescaFrancescaParadisi2012-06-132012-06-132009 Elsev2009-04-15Tetrahedron Lettershttp://hdl.handle.net/10197/3638A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, starting from a suitable N-chloroacetamide in the presence of an aqueous solution of sodium hydroxide. Piperazine-2,5-diones were obtained with excellent selectivity in yields of up to 90%.312320 bytesapplication/mswordenThis is the author’s version of a work that was accepted for publication in Tetrahedron Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron Letters (2009) DOI: 10.1016/j.tetlet.2009.01.146DiketopiperazineChloroacetamidePhase transfer catalystTEBAOrganic cyclic compounds--SynthesisPhase-transfer catalystsJournal Article50151748175010.1016/j.tetlet.2009.01.146https://creativecommons.org/licenses/by-nc-sa/1.0/