Rosales, IvonneIvonneRosalesSalazar, LauraLauraSalazarLuna, DanielDanielLunaRodriguez, Brian J.Brian J.Rodriguezet al.2021-03-022021-03-022021 the A2021-01American Journal of Molecular Biology2161-6620http://hdl.handle.net/10197/12004Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases; 2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field.enThis work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.AmyloidNeurodegenerative disordersSelf-assemblyPiezoelectricityJournal Article1111410.4236/ajmb.2021.1110012020-12-18IN210119https://creativecommons.org/licenses/by/3.0/ie/