Daly, ConorConorDalyYin, JunJunYinKennedy, BreandánBreandánKennedy2020-09-222020-09-222016 Sprin2015-10-02978-3-319-17120-30065-2598http://hdl.handle.net/10197/11586The 16th International Symposium on Retinal Degeneration (RD2014), Pacific Grove, California, United States of America, 13-18 July 2014Previous studies report that retinitis pigmentosa (RP) patients treated with the histone deacetylase inhibitor (HDACi) valproic acid (VPA) present with improved visual fields and delayed vision loss. However, other studies report poor efficacy and safety of HDACi in other cohorts of retinal degeneration patients. Furthermore, the molecular mechanisms by which HDACi can improve visual function is unknown, albeit HDACi can attenuate pro-apoptotic stimuli and induce expression of neuroprotective factors. Thus, further analysis of HDACi is warranted in pre-clinical models of retinal degeneration including zebrafish. Analysis of HDAC expression in developing zebrafish reveals diverse temporal expression patterns during development and maturation of visual function.enThe final publication is available at www.springerlink.com.Histone deacetylaseHistone deacetylase inhibtorsRetinal degen­erationRetinitis pigmentosaZebrafishBook Chapter10.1007/978-3-319-17121-0_61https://creativecommons.org/licenses/by-nc-nd/3.0/ie/26427446