Halasz, MelindaMelindaHalaszSzekeres-Bartho, JuliaJuliaSzekeres-Bartho2013-11-282013-11-282013 Elsev2013-03Journal of Reproductive Immunologyhttp://hdl.handle.net/10197/5006With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signalling events. Membrane-bound progesterone receptors have been implicated in the rapid non-genomic actions of progesterone. Both genomic and extra-nuclear actions of progesterone are crucial for adequate decidualisation and implantation. Progesterone plays a role in establishing uterine receptivity by blocking the proliferative effect of oestrogen, by inducing genes that allow the endometrium to permit embryo attachment, and also acts as a negative regulator of trophoblast invasion by controlling matrix metalloproteinase (MMP) activity.enThis is the author's version of a work that was accepted for publication in Journal of Reproductive Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Reproductive Immunology (97, 1, (2013)) DOI: http://dx.doi/org/10.1016/j.jri.2012.10.011ProgesteroneTrophoblastInvasionSignallingJournal Article971435010.1016/j.jri.2012.10.0112013-11-27https://creativecommons.org/licenses/by-nc-nd/3.0/ie/