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  5. Surface Plasmon Resonance Induced Photothermal Lysis of the Cell
 
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Surface Plasmon Resonance Induced Photothermal Lysis of the Cell

Author(s)
Gordon, John David  
Zerulla, Dominic  
Uri
http://hdl.handle.net/10197/10481
Date Issued
2018-07-26
Date Available
2019-05-16T07:52:01Z
Abstract
Cell Lysis is the imperative first step towards obtaining the intracellular contents, which hold valuable genetic and pathogenic information. The process must be carried out with extreme care to avoid damaging or altering the cell contents or indeed test conditions. As the resulting clinical information is so important, it is an intensively researched topic. Here we examine the resulting photothermal effects when a human cell in aqueous solution is brought in contact with the nobel metal film of a Kretschmann-configuration Surface Plasmon Resonance setup. This specifically targets cells of refractive index in a known desired range, activating only when the target species comes in contact with the metal film and only while possessing the correct refractive index. Depending on the desired application, this can then denature the thin cell membrane, while also generating isotropically scattered transmission light from the radiatively-decaying plasmon, which is useful for signalling. Furthermore, with simple laser intensity, selective cellular necrosis may be induced. We apply the technique specifically towards the Plasmodium falciparum-infected red blood cells.
Sponsorship
Enterprise Ireland
Science Foundation Ireland
Type of Material
Conference Publication
Publisher
IEEE
Copyright (Published Version)
2018 IEEE
Subjects

Refractive index

Plasmons

Red blood cells

Optical surface waves...

Microfluidics

Silver

Language
English
Status of Item
Peer reviewed
Conference Details
The 18th IEEE International Conference on Nanotechnology (IEEE NANO 2018), Cork, Ireland, 26-26 July 2018
ISBN
978-1-5386-5336-4
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
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Surface Plasmon Resonance Induced Photothermal Lysis of the Cell.pdf

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Owning collection
Physics Research Collection

Item descriptive metadata is released under a CC-0 (public domain) license: https://creativecommons.org/public-domain/cc0/.
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