Surface Plasmon Resonance Induced Photothermal Lysis of the Cell

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Title: Surface Plasmon Resonance Induced Photothermal Lysis of the Cell
Authors: Gordon, John David
Zerulla, Dominic
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Date: 26-Jul-2018
Online since: 2019-05-16T07:52:01Z
Abstract: Cell Lysis is the imperative first step towards obtaining the intracellular contents, which hold valuable genetic and pathogenic information. The process must be carried out with extreme care to avoid damaging or altering the cell contents or indeed test conditions. As the resulting clinical information is so important, it is an intensively researched topic. Here we examine the resulting photothermal effects when a human cell in aqueous solution is brought in contact with the nobel metal film of a Kretschmann-configuration Surface Plasmon Resonance setup. This specifically targets cells of refractive index in a known desired range, activating only when the target species comes in contact with the metal film and only while possessing the correct refractive index. Depending on the desired application, this can then denature the thin cell membrane, while also generating isotropically scattered transmission light from the radiatively-decaying plasmon, which is useful for signalling. Furthermore, with simple laser intensity, selective cellular necrosis may be induced. We apply the technique specifically towards the Plasmodium falciparum-infected red blood cells.
Funding Details: Enterprise Ireland
Science Foundation Ireland
Type of material: Conference Publication
Publisher: IEEE
Copyright (published version): 2018 IEEE
Keywords: Refractive indexPlasmonsRed blood cellsOptical surface wavesMicrofluidicsSilver
Language: en
Status of Item: Peer reviewed
Conference Details: The 18th IEEE International Conference on Nanotechnology (IEEE NANO 2018), Cork, Ireland, 26-26 July 2018
ISBN: 978-1-5386-5336-4
Appears in Collections:Physics Research Collection

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