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Thiol redox homeostasis in neurodegenerative disease
Date Issued
2015-08
Date Available
2015-06-22T11:24:05Z
Abstract
This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc− cystine–glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed.
Other Sponsorship
European Cooperation In Science and Technology
Type of Material
Journal Article
Publisher
Elsevier
Journal
Redox Biology
Volume
5
Start Page
186
End Page
194
Copyright (Published Version)
2015 the Authors
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
File(s)
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Name
2015_McBean_et_al_Redox_Biology.pdf
Size
1.08 MB
Format
Adobe PDF
Checksum (MD5)
c210124161ea324d0c5092e6709c26d0
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