Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

Author(s)
Uri
Date Issued
2009
Date Available
2012-06-26T14:09:16Z
Abstract
Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence of fluorotyrosine may result in an improvement of the biological properties of this lipopeptide. The fluorinated iturin might also be used as a probe for studying its interaction with biological membranes.
Sponsorship
Irish Research Council for Science, Engineering and Technology
Type of Material
Journal Article
Publisher
RSC Publishing
Journal
Organic and Biomolecular Chemistry
Volume
7
Issue
4
Start Page
644
End Page
646
Copyright (Published Version)
2009 the authors
Subjects

Fluorine

Antibiotic

Subject – LCSH
Fluorine
Antibiotics--Synthesis
Bacillus subtilis
DOI
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Owning collection
Biomolecular and Biomedical Science Research Collection
Mapped collections
CSCB Research Collection