Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

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Title: Functional proteomics to dissect tyrosine kinase signalling pathways in cancer
Authors: Kolch, Walter
Pitt, Andrew
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Date: 19-Aug-2010
Online since: 2013-11-29T10:11:43Z
Abstract: Advances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)–ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics.
Type of material: Journal Article
Publisher: Nature Publishing Group
Journal: Nature Reviews Cancer
Volume: 10
Issue: 9
Start page: 618
End page: 629
Copyright (published version): 2010 Nature Publishing Group
Keywords: Functional proteomicssignal transduction pathwayscancerepidermal growth factor receptor (EGFR)ERKbreakpoint cluster region (BCR)–ABL1
DOI: 10.1038/nrc2900
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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