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Formulation strategies to improve oral peptide delivery
Date Issued
2014-05
Date Available
2016-01-07T10:18:52Z
Abstract
Delivery of peptides by the oral route greatly appeals due to commercial, patient convenience and scientific arguments. While there are over 60 injectable peptides marketed worldwide, and many more in development, most delivery strategies do not yet adequately overcome the barriers to oral delivery. Peptides are sensitive to chemical and enzymatic degradation in the intestine, and are poorly permeable across the intestinal epithelium due to sub-optimal physicochemical properties. A successful oral peptide delivery technology should protect potent peptides from presystemic degradation and improve epithelial permeation to achieve a target oral bioavailability with acceptable intra-subject variability. This review provides a comprehensive up-to-date overview of the current status of oral peptide delivery with an emphasis on patented formulations that are yielding promising clinical data.
Sponsorship
Department of Agriculture, Food and the Marine
European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of Material
Journal Article
Publisher
Future Science
Journal
Pharmaceutical Patent Analyst
Volume
3
Issue
3
Start Page
313
End Page
336
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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