Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures

Files in This Item:
Access to this item has been restricted by the copyright holder until:2018-09-26
File Description SizeFormat 
Curran_et_al_2017.pdf2.09 MBAdobe PDFDownload    Request a copy
Title: Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures
Authors: Curran, Aoife M.
Fogarty Draper, Colleen
Scott-Boyer, Marie-Pier
Roche, Helen M.
Ryan, Miriam F.
Gibney, Michael J.
Brennan, Lorraine
et al.
Permanent link: http://hdl.handle.net/10197/9151
Date: 26-Sep-2017
Abstract: Validated protein biomarkers are needed for assessing health trajectories, predicting and subclassifying disease, and optimizing diagnostic and therapeutic clinical decision-making. The sensitivity, specificity, accuracy, and precision of single or combinations of protein biomarkers may be altered by differences in physiological states limiting the ability to translate research results to clinically useful diagnostic tests. Aptamer based affinity assays were used to test whether low abundant serum proteins differed based on age, sex, and fat mass in a healthy population of 94 males and 102 females from the MECHE cohort. The findings were replicated in 217 healthy male and 377 healthy female participants in the DiOGenes consortium. Of the 1129 proteins in the panel, 141, 51, and 112 proteins (adjusted p < 0.1) were identified in the MECHE cohort and significantly replicated in DiOGenes for sexual dimorphism, age, and fat mass, respectively. Pathway analysis classified a subset of proteins from the 3 phenotypes to the complement and coagulation cascades pathways and to immune and coagulation processes. These results demonstrated that specific proteins were statistically associated with dichotomous (male vs female) and continuous phenotypes (age, fat mass), which may influence the identification and use of biomarkers of clinical utility for health diagnosis and therapeutic strategies.
Funding Details: Department of Agriculture, Food and the Marine
European Commission
Type of material: Journal Article
Publisher: American Chemical Society
Copyright (published version): 2017 ACS
Keywords: Proteomics;Phenotype;Biomarker;Sex;Male;Female;Age;Fat mass;Protein;Pathway
DOI: 10.1021/acs.jproteome.7b00501
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Public Health, Physiotherapy and Sports Science Research Collection
Agriculture and Food Science Research Collection

Show full item record

SCOPUSTM   
Citations 50

1
Last Week
0
Last month
checked on Jun 23, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.